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Image of Rhodiola Rosea
Rhodiola Rosea:
Rhodiola is indigenous to the Arctic and Alpine regions of Europe, Asia and America and has long been used as a tonic by many cultures, including the Ancient Greeks. Rhodiola is an adaptogen that has been used for centuries and validated for its beneficial effects on energy production and reduction of fatigue. Furthermore, Rhodiola has been recognized in clinical studies for its ability to increase the body's capacity to adapt to stressful conditions. SociaTropinTM's Rhodiola extract is standardized to contain a minimum 5% Rosavins, the highest potency available.*
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Scientific Evidence Source Publication Year Title Results
Department of Neurology, Armenian State Medical University, Yerevan, Armenia. Nordic Journal of Psychiatry 2007 Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression Overall depression, insomnia, emotional stability and somatization improved significantly with medication of SHR-5
Centre of Sanitary and Epidemiological Inspection of the R.F. Ministry of Health, Moscow, Russia. Phytomedicine - International journal of Phytotherapy and Phytopharm - acology 2003 A randomized trial of 2 different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Pronounced anti fatigue effects
Department of Pharmaceutical Technology and Pharmacy Organization, Kaunas University of Medicine, A. Mickeviciaus 9, 44307 Kaunas, Lithuania. Medicina (Kaunas, Lithuania) 2004 Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine Adaptogenic characteristics. Increased ability to concentrate, mental and physical power, improves resistance against infection.
Faculty of Physical Education and Physiotherapy in the Exercise Physiology and Biomechanics Laboratory at the Katholieke Universiteit Leuven, Tervuursevest 101, B-3001 Leuven, Belgium. International Journal of Sport nutrition and exercise metabolism 2004 Acute Rhodiola rosea intake can improve endurance exercise performance. Improves muscle strength, exercising ability and attention
Volgograd Medical Academy, Russia. Phytomedicine - International journal of Phytotherapy and Phytopharma - cology 2000 A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Improved physical fitness and mental fatigue
Department of Neurology, Armenian State Medical University, Yerevan Phytomedicine - International journal of Phytotherapy and Phytopharma - cology 2000 Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Reduces mental fatigue under specific conditions of stress.
Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. Phytomedicine - International journal of Phytotherapy and Phytopharma - cology 2009 The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats Improves serotonin level thereby helps minimize depression.
Image of L-Theanine
L-Theanine (as SunTheanine):
L-Theanine is a unique amino acid commonly found in Green Tea. Tea leaves are a natural source of L-Theanine, however, only 1 - 2 % of the dry weight of tea leaves consists of L-Theanine. It is a very time consuming and expensive process to extract L-Theanine from tea leaves, and impossible to yield a 100% purity naturally. One of the pioneers of Green Tea Extract, Taiyo Kagaku Co. of Japan, has developed a patented enzymatic technology to synthesize 100% pure L-Theanine (SunTheanine). It is the highest-quality L-Theanine available today and it is the only form of L-Theanine utilized in the proprietary SociaTropinTM formula. L-Theanine promotes relaxation without the drowsiness or negative side effects associated with other calming agents. Human clinical trials have shown SunTheanine to promote an alert state of relaxation without drowsiness, as indicated by an increase in Alpha brain waves, and a decrease in Beta brain waves. Additional human clinical research suggests that SunTheanine may have application in improving the quality of sleep, diminishing normal symptoms of premenstrual syndrome (PMS), improving learning performance, heightening mental acuity, promoting concentration, reducing negative side effects of caffeine and supporting the immune system.*
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Scientific Evidence Source Publication Year Title Results
Carolyn Perrini, CLS, CNC web-us.com 2005 How a Unique Anxiety Reducer and Mood Enhancer Increases Alpha Waves and Alertness Calming effect, deep relaxation, increased mental alertness, improved memory and learning ability noted. Non drowsy
Unilever Food and Health Research Institute, Olivier van Noortlaan 120, Postbus 114, 3130 AC Vlaardingen, The Netherlands. Asia Pacific Journal of Clinical Nutrition 2008 L-theanine, a natural constituent in tea, and its effect on mental state Does not sedate. Significant effect observed on normal dietary levels. Effects include mental alertness and attention.
Division of Rheumatology, Allergy & Immunology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston Nutrition reviews 2008 L-theanine intervention enhances human gammadeltaT lymphocyte function. Decreased incidence of cold and flu. Enhanced lymphocyte function. Thus improving immunity against infection
Justus-Liebig-University of Giessen, D 35392 Giessen, Germany Nutrional neuroscience 2007 Source density analysis of the human EEG after ingestion of a drink containing decaffeinated extract of green tea enriched with L-theanine and theogallin. EEG observations- increased mental performance, high degree of relaxation and improved attention.
Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, UK. Biological Psychology 2008 The effects of L-theanine, caffeine and their combination on cognition and mood. Combined effects - improved mental fatigue, numeric working, memory reaction time and sentence verification accuracy. Increased alertness and reduced headache and tiredness.
Nagoya University Department of Psychology, Chikusa-ku, Nagoya, 464-8601, Japan. Biological Psychology 2007 L-Theanine reduces psychological and physiological stress responses. Anti stress effects by inhibiting cortical neuron receptors.
Cognitive Neurophysiology Laboratory, Nathan S. Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, Orangeburg, NY 10962 and Program in Cognitive Neuroscience, Department of Psychology, City College of the City University of New York, New York, NY 10031 American Society for nutrition - Proceedings of the Fourth International Scientific Symposium on Tea and Human Health 2008 L-theanine and caffeine in combination affect human cognition as evidenced by oscillatory alpha-band activity and attention task performance. Combined effects facilitated behavioral performance
Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan. Phytotherapy research 2008 Theanine prevents memory impairment induced by repeated cerebral ischemia in rats. Prevents memory impairment by protecting against neuronal cell death.
Research, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie, Japan , Research, Q-Tech Services, Inc., Crossville, TN, The Journal of the Federation of American Societies for Experimental Biology.   Efficacy (against premenstrual syndrome) and short term safety of L-theanine in a randomized, double-blind, parallel-group study in humans. Reduces PMS symptoms
COE Program in the 21st Century and Cooperation of Innovative Technology and Advanced Research in the Evolutional Area (CITY AREA), University of Shizuoka, Japan. Bioscience, Biotechnology and Biochemistry 2008 Effects of L-theanine, a unique amino Acid in tea leaves, on memory. Long term theanine consumption improved recognition, learning and memory.
Image of 5-HTP
5-HTP:
5-HTP (5-Hydroxytryptophan) is the direct metabolic precursor of serotonin and is important for the production of melatonin. 5-HTP is an extract of Griffonia simplicifolia seeds from coastal West Africa and the 5-HTP in SociaTropinTM has been verified to be free of "peak X" contaminant. SociaTropinTM utilizes the safest, highest-quality 5-HTP extract available today.*
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Scientific Evidence Source Publication Year Title Results
Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan. Molecular Brain   Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice Link between tryptophan metabolism and mental status. Modulates anxiety related behavior
Image of St. Johns Wort
St. Johns Wort (Hypericum perforatum):
The golden-yellow flowers of the St. John's Wort plant are used to derive Hyperforin and Hypericin, active components which are clinically shown to support the availability of important neurotransmitters like Serotonin, Norepinephrine, Dopamine and GABA. Scientific research shows that St. John's Wort may lighten mood and support a positive emotional balance. In addition, St. Johns Wort is commonly prescribed throughout the world to promote positive mood balance, especially during seasonal changes. SociaTropinTM's St. John's Wort is standardized to contain 0.3% hypericin.*
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Scientific Evidence Source Publication Year Title Results
1 School of Medicine, The University of Queensland , Royal Brisbane and Women's Hospital, Queensland, Brisbane, Australia . Journal of Alternative and complementary medicine 2009 Kava and St. John's Wort: Current Evidence for Use in Mood and Anxiety Disorders. Treats Mild to moderate depression
Abarbanel Mental Health Center Harefuah 2009 Hypericum extract for treatment of depression: what's new? Effective in treating mild to moderate depression with fewer side effects.
Max Zeller Söhne Zeller AG, Seeblickstr. 4, CH-8590 Romanshorn, Switzerland. axel. brattstroem@zellerag.ch Phytomedicine - International journal of Phytotherapy and Phytopharma - cology 2009 Long-term effects of St. John's wort (Hypericum perforatum) treatment: a 1-year safety study in mild to moderate depression. Safe and effective in treating long term depression without any major effects.
Centre for Complementary Medicine Research, Department of Internal Medicine II, Technische Universitaet Muenchen, Wolfgangstr. 8, Munich, Germany, 81667. Cochrane database of systematic reviews 2008 St John's wort for major depression. As effective as other antidepressants but minimum side effects than other standard antidepressants.
Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry and Psychotherapy, Eschenallee 3, 14050 Berlin, Germany. BMJ 2005 Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomized controlled double blind non-inferiority trial versus paroxetine. As effective as Paroxetine and is well tolerated
Image of Cyracos Lemon Balm
Cyracos Lemon Balm:
Lemon balm (Melissa officinalis), a plant native to the Mediterranean region, has been clinically proven to reduce anxiety by 49% and sleeplessness by up to 39% in as little as 15 days. What's more, lemon balm produces these calming effects while also enhancing memory and attention. The lemon balm in SociaTropinTM is prepared from special lemon balm chosen for its high concentrations of hydroxycinnamic and rosmarinic acids. These active lemon balm constituents appear to enhance mood and cognitive performance by exhibiting central nervous system acetylcholine receptor activity, including nicotinic and muscarinic binding properties in the cerebral cortex of the human brain.*
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Scientific Evidence Source Publication Year Title Results
Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK. david.kennedy@unn.ac.uk Phytotherapy Research 2006 Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Lemon balm in combination with Valeriana produces anxiolytic effects.
American psychosomatic Society Pyschosomatic medicine 2004 Attenuation of Laboratory-Induced Stress in Humans After Acute administration of Lemon Balm Acute administration of Lemon balm can ameliorate mood. Improved calmness and decreased alertness observed.
Dr. Willmar Schwabe Pharmaceuticals, Karlsruhe, Germany. Phytomedicine 2006 A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children. Dyssomnia and restlessness reduced from severe to mild forms
Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, UK. Neuropsycho - pharmacology 2003 Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Improves cognitive performance and mood
Image of Ginkgo Biloba
Ginkgo Biloba:
For nearly 2800 years the Chinese have used extracts from the Ginkgo biloba tree to treat a variety of conditions to maintain the healthy normal function of the brain, cardiovascular, blood and blood vessels, circulatory, and metabolic processes. Ginkgo contains numerous antioxidants such as the proanthocyanidins and flavonoids, which counteract free radical activity. Flavonoids are also known to strengthen capillaries, which can promote healthy blood flow to the brain, helping to maintain cognitive health. People often associate ginkgo with healthy cognitive function, but a review of hundreds of published studies reveals that this flavonoid probably benefits every cell in the body. It is known to protect the energy-producing mitochondria in the cells, thus enhancing oxygen utilization and cellular respiration.*
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Scientific Evidence Source Publication Year Title Results
University of Osnabrueck, Germany. Human Psychopharma - cology 2009 Ginkgo biloba: specificity of neuropsychological improvement--a selective review in search of differential effects. Chronic administration improves attention
Kilguss Research Institute, Women and Infants Hospital, Brown University, Providence, RI 02905, USA. Phytotherapy research 2007 Antidepressant and antistress activity of GC-MS characterized lipophilic extracts of Ginkgo biloba leaves. Identifies the bioactive compound in the leaves
Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 Bld LaSalle, Verdun, Québec, Canada. European Journal of Neuroscience 2000 The ginkgo biloba extract (EGb 761) protects hippocampus neurons against cell death induced by ß-amyloid Has neuroprotective effects - Inhibits Abeta induced toxicity and cell death. Effective in treatment of Alzheimer's.
Institute for BioScience, 153 West Main Street, Westboro, MA 01581, USA Current drug targets 2000 Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications. Proves the anti stress effect and neuroprotective effects in Gingko Biloba
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA. Proceedings of the National Academy of Sciences of the United States of America. 2001 The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba. Neuromodulatory effects observed
Klinik für Psychiatrie und Psychotherapie, Giessen, Germany. Journal of Psychiatric research 2007 Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. Enhances cognitive function and stabilizes mood. Alleviates anxiety.
Department of Public Health, Oregon State University, Corvallis, OR 97401, USA. Hiroko. Dodge@oregonstate.edu Neurology 2009 A randomized placebo-controlled trial of Ginkgo biloba for the prevention of cognitive decline Protective effect on the progression of clinical dementia of 0.5 was observed.
Image of L-Tyrosine
L-Tyrosine:
L-Tyrosine can be converted by neurons in the brain and in the adrenal medulla of the adrenal glands to dopamine, norepinephrine (noradrenaline), and epinephrine hormones which are depleted by stress, overwork, and certain drugs. By replenishing norepinephrine in the brain, mental energy levels are enhanced and a feeling of contentment often occurs. Because of the liver conversion necessary for L-phenylalanine to have these effects, L-tyrosine is often faster acting. In addition, the conversion step from L-tyrosine to norepinephrine may be enhanced if the co-factors (vitamins B6 and C) are included.*
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Scientific Evidence Source Publication Year Title Results
Department of Human Nutrition and Metabolism, Hadassah Medical School, Hebrew University, Jerusalem, Israel. Pharmacology, Biochemistry and Behavior 2001 Separation-induced body weight loss, impairment in alternation behavior, and autonomic tone: effects of tyrosine. Therapy for cognitive and mood problems
U.S. Army Soldier Research, Development and Engineering Center, Kansas Street, Natick, MA 01760-5020, USA Science Direct 2007 Tyrosine supplementation mitigates working memory decrements during cold exposure Tyrosine supplementation in cold exposure helps alleviate working memory
Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760, USA. Science Direct 2007 Dietary tyrosine benefits cognitive and psychomotor performance during body cooling. Tyrosine supplementation in cold temperature helps improve cognitive, psychomotor and physical performance.
Department of Neuroscience, Psychiatry, Ulleråker, Uppsala University Hospital, Uppsala SE-750 17, Sweden. Schizophrenia Research 2005 Kinetics of tyrosine transport and cognitive functioning in schizophrenia. Changes in tyrosine transport influence cognitive functioning through dopamine system
Image of Bacopa
Bacopa:
Studies show that Bacopa (Bacopa Monniera) is a mild sedative which supports the body during periods of emotional stress. Traditionally, Bacopa is prescribed to promote healthy cognitive functions, including focus, concentration, mental endurance and memory.*
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Scientific Evidence Source Publication Year Title Results
Helfgott Research Institute, National College of Natural Medicine, Portland, OR 97201, USA Journal of Alternative and Complementary medicine 2008 Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. Enhances cognitive performance in the aged safely.
Department of Psychology, University of Wollongong, Woolongong, Australia. steven_rooden rys@uow.edu.au Neuropsycho - pharmacology 2002 Chronic effects of Brahmi (Bacopa monnieri) on human memory. Decreases the rate of forgetting newly acquired information
Neuropsychology Laboratory, School of Biophysical Science and Electrical Engineering, Victoria, Australia. Psychopharma - cology 2001 The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Improves learning and memory
  Alternative medicine review - A journal of Clinical therapeutic. 1999 A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Anti anxiety, Anti fatigue and memory strengthening effects.
Brain Sciences Institute, Swinburne University, Hawthorn, Victoria 3122, Australia. Phytotherapy research 2008 Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Enhances cognitive effects in healthy humans
Department of Neurology, Scott and White Clinic, Texas A&M University System HSC College of Medicine, Temple, Texas, USA. . Phytotherapy research 2007 Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Reduces beta amyloid levels in the brain, thus helpful in the treatment of Alzheimer's
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. Phytomedicine - International journal of phytotherapy and Phytopharma - cology 2002 Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Antidepressant activity compared to that of Imipramine observed.
Image of Sensoril Ashwagandha
Sensoril Ashwagandha (Withania somnifera):
Sensoril Ashwagandha is a patented Ashwagandha extract obtained from roots and leaves and is standardized to contain a minimum of 8% withanolide glycosides, a minimum of 32% oligosachharides and a maximum of 2% withaferin A. Ashwagandha has been used in the Indian tradition of Ayurveda to improve musculoskeletal function and as a tonic to improve overall health. Experimental studies demonstrate that Ashwagandha is an antioxidant that supports joint mobility and resistance to fatigue.*
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Scientific Evidence Source Publication Year Title Results
M.L. Sukhadia University, Udaipur, 313001, India Neurochemical research 2009 Neuroprotective Effects of Withania somnifera Dunal.: A Possible Mechanism. Therapeutic effect for stress induced neurological disorders.
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. Journal of medicinal Food 2009 Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington's disease. Neuroprotective effects
Department of Pharmacology, B.N. College of Pharmacy, Udaipur. Indian journal of physiology and pharmacology 2007 Protective effect of Withania somnifera dunal root extract against protracted social isolation induced behavior in rats. Mood stabilizer
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India. Indian journal of Experimental Biology 2007 Protective effect of Withania somnifera Dunal on the behavioral and biochemical alterations in sleep-disturbed mice (Grid over water suspended method). Management of sleep loss
National Botanical Research Institute, Rana Pratap Marg, Lucknow-226001, (U.P.) India. Biochimica et Biophysica Acta 2007 Purification and physico-kinetic characterization of 3beta-hydroxy specific sterol glucosyltransferase from Withania somnifera (L) and its stress response. Sterol glucosyltransferase from the leaves of this plant was found to play a role in abiotic and biotic stress
Image of Panax Ginseng
Panax Ginseng (Panax quinquefolius L.):
A perennial herb that is indigenous to the Appalachian mountain region of North America. It is chemically similar to Oriental Ginseng and widely used for its adaptogenic properties, which support the body during periods of emotional stress. American Ginseng is often prescribed to promote alertness and mental acuity.*
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Scientific Evidence Source Publication Year Title Results
Research Center of Pharmacology and Toxicology, Peking Union Medical College, Institute of Medicinal Plant Development, Beijing, 100193, PR China. Progress in Neuropsycho - pharmacology and Biological Psychiatry 2009 Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression. Antidepressant effects of Ginseng total saponins
Cognitive Drug Research Ltd, Reading, UK. Psychopharma - cology 2000 The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Memory enhancing effects
School of Pharmacy, University of Connecticut, Storrs, USA. The Annals of Pharmaco - therapy 2002 Effects of Panax ginseng on quality of life. Improves mental health and social functioning
Department of Pharmacology, Postgraduate Institute of Basic Medical Sciences, Calcutta University, 244 B Acharya JC Bose Road, Calcutta 700 020, India. Pharmacology, Biochemistry and Behavior 2003 Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Significant antistress adaptogenic activity
Department of Pharmacology, Banaras Hindu University, Varanasi, India. Journal of Ethnopharma - cology 1991 Anxiolytic activity of Panax ginseng roots: an experimental study. Anxiolytic activity
Department of Experimental Pharmacology, University of Naples Federico II, via D. Montesano 49, Naples, Italy. Fitoterapia 2000 The aphrodisiac and adaptogenic properties of ginseng. Enhances physical performance, promotes vitality and increases resistance to stress and ageing
Image of Bioactive Forms of Essential B Vitamins
Bioactive Forms of Essential B Vitamins:
B vitamins are water soluble and must be replenished daily for the body to operate at peak energy. SociaTropinTM features high levels of B6, B12, and other B vitamins for healthy blood, brain, and nerve cell function, which are all essential for sustained energy. The B vitamins in SociaTropinTM support vitality, endurance, and help maintain mental alertness when experiencing fatigue.*
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Scientific Evidence Source Publication Year Title Results
MRC Neuropsychiatric Research Laboratory, Epsom, Surrey, UK. Journal of psychopharma - cology 2005 Treatment of depression: time to consider folic acid and vitamin B12 Oral doses of Folic acid and Vitamin B12 helps improve treating depression
Medical University of Lublin, The Department of Psychiatry, Poland. karakulahw@cyberia.pl   2009 Does diet affect our mood? The significance of folic acid and homocysteine Vitamin B12,B6 and folic acid are required in the diet to prevent depression and mood disorders
  Current Molecular medicine 2009 Folic acid, neurodegenerative and neuropsychiatric disease. Vitamin B plays important role in antidepressant pharmacotherapy.
Department of Epidemiology and Biostatistics, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands. American Psychiatric Association 2002 Vitamin B12, Folate, and Homocysteine in Depression: The Rotterdam Study Vitamin B12 and Folate deficiency related to depressive disorders
Image of Valerian
Valerian:
The root of Valerian, a tall perennial herb with white to pinkish-purple flowers, is used as a natural sedative to relax the Central Nervous System (CNS). Valerian is widely prescribed to alleviate anxiety in moderate doses and to improve overall sleep quality when administered in higher doses.
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Scientific Evidence Source Publication Year Title Results
Department of Pharmacology and Toxicology, Universitätsklinikum Münster, Westfälische Wilhelms-Universität Münster, Domagkstr. 12, 48149 Münster, Germany. Phytomedicine 2008 Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. Anxiolytic and antidepressant activity
Department of Pharmacology, Institute of Post Graduate Medical Education and Research, Kolkata, India. Nepal Medical College Journal 2007 Initial exploratory observational pharmacology of Valeriana wallichii on stress management: a clinical report. Anti stress agent
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. Biological and Pharmaceutical bulletin 2007 Effect of valerian extract preparation (BIM) on the sleep-wake cycle in rats. Sleep inducing effect without altering sleep-wakefulness cycle.
Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Florida 33136, USA. Cultural Diversity and Ehtnic Minority Psychology 2000 Valerian as a hypnotic for Hispanic patients. Improves insomnia
Facultad de Farmacia y Bioquímica, Instituto de Química y Fisicoquímica Biológicas, Junín 956 (1113), Buenos Aires, Argentina. Pharmacology, Biochemistry and Behavior 2003 6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS. Sedative, sleep enhancing properties and Anxiolytic properties
Department of Pharmacy, King's College London. The journal of pharmacy and Pharmacology 1999 The scientific basis for the reputed activity of Valerian. General sedative or tranquilizing effect
New Product Division, Rohto Pharmaceutical Co., Ltd., Osaka, Japan. Chemical and Pharmaceutical Bulletin 1992 Psychotropic effects of Japanese valerian root extract. Antidepressant
Foellinge Health Center, Sweden. Pharmacology, Biochemistry and Behavior 1989 Double blind study of a valerian preparation. Improved sleep in patients
Image of Passion Flower
Passion Flower:
The brightly-colored flowers and aerial (above ground) portions of the Passion Flower vine are used to derive medicinal compounds that relax the Central Nervous System (CNS). Passion Flower is commonly used to reduce overactive behaviors, including restlessness, nervousness and mild anxiety.
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Scientific Evidence Source Publication Year Title Results
Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran, Iran. Journal of Clinical Pharmacy and Therapeutics. 2001 Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. Effective drug for anxiety
Institut für Pharmakognosie, Universität Wien, Althanstrasse 14, A-1090 Wien. Liselotte. Wiener medizinische Wochenschrift 2002 [Passion Flower (Passiflora incarnata L.)--a reliable herbal sedative] Helps relieving restlessness, irritability and difficulty in sleeping.
Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, Brazil. Journal of medicinal food 2008 The aqueous extracts of Passiflora alata and Passiflora edulis reduce anxiety-related behaviors without affecting memory process in rats. Anxiolytic effects without affecting memory
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